STKE: Plaguing Caspase-1 Through Rac

Rac 1 protects epithelial cells against anoikis 1 1 Rac 1 protects epithelial cells against anoikis

Caspase - 11 Controls Interleukin - 1 β Release through Degradation

Apoptosis Through Caspase Activation HIV-1 Tat Induces Microvascular Endothelial

Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation.

The lifelong self-renewal of the epidermis is driven by a progenitor cell population with high proliferative potential. To date, the upstream signals that determine this potential have remained largely elusive. Here, we find that insulin and insulin-like growth factor receptors (IR and IGF-1R) determine epidermal proliferative potential and cooperatively regulate interfollicular epidermal morph...

keratinocyte polarity through integrin - mediated modulation of Rac 1 and cofilin activities

 integrin, a component of hemidesmosomes, also plays a role in keratinocyte migration via signaling through Rac1 to the actin-severing protein cofilin. Here, we tested the hypothesis that the 4 integrin-associated plakin protein, bullous pemphigoid antigen 1e (BPAG1e) functions as a scaffold for Rac1/ cofilin signal transduction. We generated keratinocyte lines exhibiting a stable knockdow...